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Day 24

A collection of 3 issues

74 ALLERGY & HYPERSENSITIVITY

# Allergy & Hypersensitivity Hypersensitivity is an exaggerated or inappropriate immune response to an antigen that would normally be harmless or only mildly noxious. The damage is done by the immune system, not the antigen itself. The Gell-Coombs classification (I–IV) remains the framework MRCS examiners use, and almost every

35 CAUSATIVE PATHOGEN

# 36 CAUSATIVE PATHOGEN Why this topic matters "Match the bug to the scenario" is one of the highest-yield SBA patterns in MRCS Part A. The examiner gives you a one-line vignette — a sickle cell child with osteomyelitis, a watercress farmer with jaundice, an IVDU with cavitating

36 ANTIMICROBIALS

# 37 ANTIMICROBIALS Antimicrobials are among the most heavily examined topics in MRCS Part A. Questions test three things repeatedly: mechanism of action, spectrum and indication, and major side effects. If you can place every drug into one of six mechanism boxes, predict which bugs it covers, and recall one or